Dr. Donald G. Welsh, Ph.D.
Academic Rank: Associate Professor
Departments: Physiology & Pharmacology
Program: Vascular Biology
Location/Address
Health Research and Innovation Centre
33280 Hospital Drive NW Rm GAA14
Calgary, Alberta T2N 4Z6
Tel: 403.210.3819
Summary of Research Interests
- Electrophysiological Basis of Smooth Muscle Contraction.
- Cell-Cell Communication in Resistance Arteries.
- Kinase Regulation of Ion Channels.
Recent Publications
Luykenaar KD, Abd-El Rahman R, Walsh MP, Welsh DG. Rho-kinase-mediated suppression of KDR channels requires an intact actin cytoskeleton. American Journal of Physiology (Heart & Circulation Physiology). 294: H917-H926, 2009.
Tran CH, Vigmond EJ, Plane F, Welsh DG. Mechanistic basis of differential communication in skeletal muscle arteries. Journal of Physiology. 587:1301-1318, 2009.
Tran CH, Welsh DG. Current perspective on differential communication in small resistance arteries. Canadian Journal of Physiology & Pharmacology. 87(1):21-8, 2009.
Sandow SL, Haddock RE, Hill CE, Chadha PS, Kerr PM, Welsh DG, Plane F. What's where and why at a vascular myoendothelial microdomain signaling complex? Clinical and Experimental Pharmacology & Physiology. 36(1):67-76, 2009.
Smith PD, Brett SE, Luykenaar KD, Sandow SL, Marrelli SP, Vigmond EJ, Welsh DG. KIR channels function as electrical amplifiers in rat vascular smooth muscle. Journal of Physiology. 586(4): 1147-60, 2008.
Corteling RL, Brett SE, Yin H, Zheng XL, Walsh MP, Welsh DG. The functional consequence of RhoA knockdown by RNA interference in rat cerebral arteries. American Journal of Physiology (Heart & Circulation Physiology). 293(1): H440-447, 2007.
Luykenaar KD, Welsh DG. Activators of the PKA and PKG pathways attenuate RhoA-mediated suppression of the KDR current in cerebral arteries. American Journal of Physiology (Heart and Circulatory Physiology). 292(6): H2654-2663, 2007. Wu BN, Luykenaar KD, Brayden JE, Giles WR, Corteling RL, Wiehler WB, Welsh DG. Hyposmotic challenge inhibits inward rectifying K+ channels in cerebral arterial smooth muscle cells. Americ. (Heart and Circulatory Physiology). 292(2):H1085-94, 2007.
Maruyama Y, Nakanishi Y, Walsh E, Wilson D, Welsh DG, Cole WC. Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7R5 vascular smooth muscle cells. Circulation Research. 98:1520-7, 2006.
Diep HK, Vigmond EJ, Segal SS, Welsh DG. Defining electrical communication in skeletal muscle resistance arteries: a computational approach. Journal of Physiology. 568:267-81, 2005. Jantzi MC, Brett SE, Jackson WF, Corteling RL, Vigmond EJ, Welsh DG. Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries. American Journal of Physiology (Heart and Circulatory Physiology). 291:H1319-H1328, 2006. Maruyama Y, Nakanishi Y, Walsh E, Wilson D, Welsh DG, Cole WC. Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7R5 vascular smooth muscle cells. Circulation Research. 98(12): 1520-1527, 2006.
Tran CH, Vigmond EJ, Plane F, Welsh DG. Biophysical properties of the vasculature govern differential communication. Canadian Cardiovascular Congress 2009.
Abd El-Rahman R, Hung King Sang J, Brett SE, Welsh DG. Role for L-type Ca2+ channels in cerebral arterial tone regulation. Canadian Cardiovascular Congress 2009.
Mufti R, Brett SE, Bradley KN, Anfinogenova Y., Jones P, Chen SR, Cole WC, Welsh DG. Intravascular pressure initiates cerebral arterial constriction by inducing voltage-independent Ca2+ waves. Canadian Cardiovascular Congress 2009.
Anfinogenova Y, Welsh DG. Electrophysiological characterization of TRPC-like current in cerebral arterial smooth muscle. Experimental Biology 2009.
Luykenaar KD, Walsh MP, Welsh DG. Rho-kinase-mediated suppression of KDR current in cerebral arteries requires an intact actin cytoskeleton. Experimental Biology 2009.
Tran CH, Vigmond EJ, Welsh DG. Mechanistic basis of differential conduction in skeletal muscle arteries. Experimental Biology 2009.
